The long-term clinical efficacy of recombinant human nerve growth factor in the treatment of neurotrophic keratitis

Topical recombinant human nerve growth factor (rhNGF) is FDA-approved to treat patients with neurotrophic keratitis (NK), but current clinical trial data only encompasses 1 year of follow up. We hypothesize that a single course of rhNGF can have a long-term, persistent effect on NK healing and related clinical parameters. Therefore, we evaluated the long-term efficacy of rhNGF in a retrospective, consecutive, observational case series from a single-center setting over a 4-year period.