The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling
Academic Article
Publication Date:
2018
abstract:
Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGGs.
Iris type:
1.1 Articolo in rivista
Keywords:
PI3K/AKT/mTORC1; paediatric low-grade gliomas; miR-139-5p; microRNAs; patients’ derived primary cells; supratentorial
List of contributors:
Catanzaro, Giuseppina; Besharat, Zein Mersini; Miele, Evelina; Chiacchiarini, Martina; Po, Agnese; Carai, Andrea; Marras, Carlo Efisio; Antonelli, Manila; Badiali, Manuela; Raso, Alessandro; Mascelli, Samantha; Schrimpf, Daniel; Stichel, Damian; Tartaglia, Marco; Capper, David; von Deimling, Andreas; Giangaspero, Felice; Mastronuzzi, Angela; Locatelli, Franco; Ferretti, Elisabetta
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