PCSK9 rs11591147 R46L Loss-of-Function Variant Protects Against Liver Damage in Individuals with NAFLD
Academic Article
Publication Date:
2020
abstract:
The proproteinconvertasesubtilisin/kexin type 9(PCSK9) plays a key role in cholesterol homeostasis, and its inhibition represents an effective therapy to lower LDL-C levels. In this study, we examined the impact of the PCSK9 rs11591147 loss-of-function (LOF) variant on liver damage in a multicenter collection of patients at risk of nonalcoholic steatohepatitis (NASH), in clinical samples and experimental models.
Iris type:
1.1 Articolo in rivista
List of contributors:
Grimaudo, Stefania; Bartesaghi, Stefano; Rametta, Raffaela; Marra, Fabio; Mancina, Rosellina Margherita; Pihlajamäki, Jussi; Kakol-Palm, Dorota; Andréasson, Anne-Christine; Dongiovanni, Paola; Fracanzani, Anna Ludovica; Lori, Giulia; Männistö, Ville; Pellegrini, Giovanni; Bohlooly-Y, Mohammad; Pennisi, Grazia; Pipitone, Rosaria Maria; Spagnuolo, Rocco; Craxì, Antonio; Lindén, Daniel; Valenti, Luca; Romeo, Stefano; Petta, Salvatore
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