Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation
Academic Article
Publication Date:
2021
abstract:
In this study we describe the generation and characterization of an human induced pluripotent stem cell (hiPSC) line from a long QT syndrome type 1 (LQT1) patient carrying the KCNQ1 c.940 G > A (p.Gly314Ser) mutation. This patient-specific iPSC line has been obtained by using non-integrational Sendai reprogramming method, expresses pluripotency markers and has the capacity to differentiate into the three germ layers and into spontaneously beating cardiomyocytes (iPSC-CMs).
Iris type:
1.1 Articolo in rivista
Keywords:
cell Line; humans; KCNQ1 potassium channel; mutation; induced pluripotent stem cells; Romano-Ward Syndrome
List of contributors:
Lavra, L.; Magi, F.; Ulivieri, A.; Morgante, A.; Paulis, M.; Sala, L.; Pedrazzini, M.; Polisca, P.; Rocchetti, M.; Calo, L.; Sciacchitano, S.; Salehi, L. B.
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