Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa
Academic Article
Publication Date:
2012
abstract:
HIV RNA monitoring is not available in most antiretroviral treatment (ART) programs in sub-Saharan Africa; switch to second-line therapy is mostly guided by clinical/immunological criteria. This may lead to unnecessary disease progression and drug resistance accumulation. We investigated the prognostic value of virological and immunological status 6 months after ART initiation with respect to death, loss to follow-up, and treatment switch.
Iris type:
1.1 Articolo in rivista
Keywords:
drug administration schedule; anti-HIV agents; humans; predictive value of tests; Africa South of the Sahara; CD4 lymphocyte count; RNA; viral; HIV-1; viral load; Kaplan-Meier estimate; prospective studies; HIV infections; patient compliance; adult; cohort studies; female; male
List of contributors:
De Luca, A; Marazzi, M; Mancinelli, Sandro; Ceffa, S; DORO ALTAN, ANNA MARIA; Buonomo, Ersilia; Prosperi, M; Pedruzzi, B; Noorjehan, A; Scarcella, Paola; Liotta, Giuseppe; Palombi, Leonardo
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