A thermostable archaeal S-adenosylmethionine synthetase: A promising tool to improve the synthesis of adenosylmethionine analogs of biotechnological interest
Academic Article
Publication Date:
2015
abstract:
The naturally and widely occurring sulfonium compound, S-adenosylmethionine (AdoMet), one of nature's most versatile molecules, is biosynthesized from methionine and ATP by AdoMet synthetase or methionine adenosyltransferase (MAT) in a 2-step reaction in which the energy-rich sulfonium compound is formed by dephosphorylation of ATP. All living cells, with the only exception of some parasites and infectious agents, express MAT.
Iris type:
1.1 Articolo in rivista
Keywords:
Adenosylmethionine synthetase; Archaea; Hyperthermophilic enzymes; Methionine adenosyltransferase; Organic solvent activity and thermostability; Pyrococcus furiosus; S-Adenosylmethionine
List of contributors:
Porcelli, M.; Ilisso, C. P.; Mosca, L.; Cacciapuoti, G.
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