Prebiotics and Probiotics - Potential Benefits in Nutrition and Health , Book edited by: Prof. Dr. Elena Franco-Robles and Joel Ramírez-Emiliano- Capitolo n.7 (total pp 19) dal Titolo ”Probiotics in Health and Immunity: A First Step toward Understanding the Importance of Microbiota System in Translational Medicine.” ,

There are mounting evidences showing the relation of chronic inflammatoryand autoimmune diseases with the uncontrolled intensification of gut dysbiosis.This position asserts that an elevated presence of pathogens and bacterial, fungal,and viral components is directly involved in inflammatory metabolic diseases witha strong alteration of autoimmune components such as in inflammatory bowelsyndrome (IBS), ulcerative colitis, and Crohn’s disease. Furthermore, the increaseof unbalanced enteric microbiota is also connected to other types of conditions ofmetabolic origin such as diabetes mellitus, atherosclerosis, and osteo-degenerativeconditions. As a matter of fact, evidence confirmed that gut damages histologicallyinspected revealed a situation with high expression of pro-inflammatory cytotumornecrosis factor-alpha (TNF-α), and IL1β, IL-2, IL-4, IL-6, and IL-17 together withhigh level of mucin-2. This chapter focuses on diverse topics related to microbiotadysfunction and systemic health condition and regenerative capacity and thetherapeutic role of probiotics in gut health and disease emphasizing the potentialbeneficial role of probiotics in idiopathic inflammatory metabolic diseases. In brief,outcomes demonstrate that an intimate relationship between microbiota, metabolism,tissue/cellular damages, and regeneration is standing. Within this scenario,the gut certainly plays a big part of the regenerative mechanisms in translationalmedicine.