Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium
Articolo
Data di Pubblicazione:
2023
Abstract:
Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Orieux, A.; Ferte, T.; Jouhet, V.; Aaron, J. R.; Agapito, G.; Albayrak, A.; Albi, G.; Alessiani, M.; Alloni, A.; Amendola, D. F.; Angoulvant, F.; Anthony, L. L. L. J.; Aronow, B. J.; Ashraf, F.; Atz, A.; Avillach, P.; Panickan, V. A.; Azevedo, P. S.; Balshi, J.; Batugo, A.; Beaulieu-Jones, B. K.; Beau-Lieu-Jones, B. R.; Bell, D. S.; Bellasi, A.; Bellazzi, R.; Benoit, V.; Beraghi, M.; Bernal-Sobrino, J. L.; Bernaux, M.; Bey, R.; Bhatnagar, S.; Blanco-Martinez, A.; Boeker, M.; Bonzel, C. -L.; Booth, J.; Bosari, S.; Bourgeois, F. T.; Bradford, R. L.; Brat, G. A.; Breant, S.; Brown, N. W.; Bruno, R.; Bryant, W. A.; Bucalo, M.; Bucholz, E.; Burgun, A.; Cai, T.; Cannataro, M.; Carmona, A.; Cattelan, A. M.; Caucheteux, C.; Champ, J.; Chen, K. Y.; Chen, J.; Chiovato, L.; Chiudinelli, L.; Cho, K.; Cimino, J. J.; Colicchio, T. K.; Cormont, S.; Cossin, S.; Craig, J. B.; Cruz-Bermudez, J. L.; Cruz-Rojo, J.; Dagliati, A.; Daniar, M.; Daniel, C.; Das, P.; Devkota, B.; Dionne, A.; Duan, R.; Dubiel, J.; Duvall, S. L.; Esteve, L.; Estiri, H.; Fan, S.; Follett, R. W.; Ganslandt, T.; Garcia-Barrio, N.; Garmire, L. X.; Gehlenborg, N.; Getzen, E. J.; Geva, A.; Gonzalez, T. G.; Gradinger, T.; Gramfort, A.; Griffier, R.; Griffon, N.; Grisel, O.; Gutierrez-Sacristan, A.; Guzzi, P. H.; Han, L.; Hanauer, D. A.; Haverkamp, C.; Hazard, D. Y.; He, B.; Henderson, D. W.; Hilka, M.; Ho, Y. -L.; Holmes, J. H.; Honerlaw, J. P.; Hong, C.; Huling, K. M.; Hutch, M. R.; Issitt, R. W.; Jannot, A. S.; Jouhet, V.; Kavuluru, R.; Keller, M. S.; Kennedy, C. J.; Kernan, K. F.; Key, D. A.; Kirchoff, K.; Klann, J. G.; Kohane, I. S.; Krantz, I. D.; Dr, D. K.; Krishnamurthy, A. K.; L'Yi, S.; Le, T. T.; Leblanc, J.; Lemaitre, G.; Lenert, L.; Leprovost, D.; Liu, M.; Loh, N. H. W.; Long, Q.; Lozano-Zahonero, S.; Luo, Y.; Lynch, K. E.; Mahmood, S.; Maidlow, S. E.; Makoudjou, A.; Makwana, S.; Malovini, A.; Mandl, K. D.; Mao, C.; Maram, A.; Maripuri, M.; Martel, P.; Martins, M. R.; Marwaha, J. S.; Masino, A. J.; Mazzitelli, M.; Mazzotti, D. R.; Mensch, A.; Milano, M.; Minicucci, M. F.; Moal, B.; Ahooyi, T. M.; Moore, J. H.; Moraleda, C.; Morris, J. S.; Morris, M.; Moshal, K. L.; Mousavi, S.; Mowery, D. L.; Murad, D. A.; Murphy, S. N.; Naughton, T. P.; Neto, C. T. B.; Neuraz, A.; Newburger, J.; Ngiam, K. Y.; Njoroge, W. F. M.; Norman, J. B.; Obeid, J.; Okoshi, M. P.; Olson, K. L.; Omenn, G. S.; Orlova, N.; Ostasiewski, B. D.; Palmer, N. P.; Paris, N.; Patel, L. P.; Pedrera-Jimenez, M.; Pfaff, A. C.; Pfaff, E. R.; Pillion, D.; Pizzimenti, S.; Priya, T.; Prokosch, H. U.; Prudente, R. A.; Prunotto, A.; Quiros-Gonzalez, V.; Ramoni, R. B.; Raskin, M.; Rieg, S.; Roig-Dominguez, G.; Rojo, P.; Rubio-Mayo, P.; Sacchi, P.; Saez, C.; Salamanca, E.; Samayamuthu, M. J.; Sanchez-Pinto, L. N.; Sandrin, A.; Santhanam, N.; Santos, J. C. C.; Sanz Vidorreta, F. J.; Savino, M.; Schriver, E. R.; Schubert, P.; Schuettler, J.; Scudeller, L.; Sebire, N. J.; Serrano-Balazote, P.; Serre, P.; Serret-Larmande, A.; Shah, M.; Abad, Z. S. H.; Silvio, D.; Sliz, P.; Son, J.; Sonday, C.; South, A. M.; Sperotto, F.; Spiridou, A.; Strasser, Z. H.; Tan, A. L. M.; Tan, B. W. Q.; Tan, B. W. L.; Tanni, S. E.; Taylor, D. M.; Terriza-Torres, A. I.; Tibollo, V.; Tippmann, P.; Toh, E. M. S.; Torti, C.; Trecarichi, E. M.; Vallejos, A. K.; Varoquaux, G.; Vella, M. E.; Verdy, G.; Vie, J. -J.; Visweswaran, S.; Vitacca, M.; Wagholikar, K. B.; Waitman, L. R.; Wang, X.; Wassermann, D.; Weber, G. M.; Wolkewitz, M.; Wong, S.; Xia, Z.; Xiong, X.; Ye, Y.; Yehya, N.; Yuan, W.; Zachariasse, J. M.; Zahner, J. J.; Zambelli, A.; Zhang, H. G.; Zoller, D.; Zuccaro, V.; Zucco, C.
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