Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19
Articolo
Data di Pubblicazione:
2021
Abstract:
Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January–September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7–7.8%, pFDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7–10.5%, pFDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19–25%), cerebrovascular diseases (24%, 13–35%), nontraumatic intracranial hemorrhage (34%, 20–50%), encephalitis and/or myelitis (37%, 17–60%) and myopathy (72%, 67–77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adolescent; Adult; Aged; Aged; 80 and over; Child; Child; Preschool; Cross-Sectional Studies; Female; Humans; Infant; Infant; Newborn; Male; Middle Aged; Prevalence; Severity of Illness Index; Young Adult; COVID-19; Nervous System Diseases; Pandemics
Elenco autori:
Le, T. T.; Gutierrez-Sacristan, A.; Son, J.; Hong, C.; South, A. M.; Beaulieu-Jones, B. K.; Loh, N. H. W.; Luo, Y.; Morris, M.; Ngiam, K. Y.; Patel, L. P.; Samayamuthu, M. J.; Schriver, E.; Tan, A. L. M.; Moore, J.; Cai, T.; Omenn, G. S.; Avillach, P.; Kohane, I. S.; Aaron, J. R.; Agapito, G.; Albayrak, A.; Alessiani, M.; Amendola, D. F.; Angoulvant, F.; Anthony, L. L. L. J.; Aronow, B. J.; Atz, A.; Balshi, J.; Bell, D. S.; Bellasi, A.; Bellazzi, R.; Benoit, V.; Beraghi, M.; Bernal Sobrino, J. L.; Bernaux, M.; Bey, R.; Blanco Martinez, A.; Boeker, M.; Bonzel, C. -L.; Booth, J.; Bosari, S.; Bourgeois, F. T.; Bradford, R. L.; Brat, G. A.; Breant, S.; Brown, N. W.; Bryant, W. A.; Bucalo, M.; Burgun, A.; Cannataro, M.; Carmona, A.; Caucheteux, C.; Champ, J.; Chen, K.; Chen, J.; Chiovato, L.; Chiudinelli, L.; Cimino, J. J.; Colicchio, T. K.; Cormont, S.; Cossin, S.; Craig, J. B.; Cruz Bermudez, J. L.; Cruz Rojo, J.; Dagliati, A.; Daniar, M.; Daniel, C.; Davoudi, A.; Devkota, B.; Dubiel, J.; Esteve, L.; Fan, S.; Follett, R. W.; Gaiolla, P. S. A.; Ganslandt, T.; Garcia Barrio, N.; Garmire, L. X.; Gehlenborg, N.; Geva, A.; Gradinger, T.; Gramfort, A.; Griffier, R.; Griffon, N.; Grisel, O.; Hanauer, D. A.; Haverkamp, C.; He, B.; Henderson, D. W.; Hilka, M.; Holmes, J. H.; Horki, P.; Huling, K. M.; Hutch, M. R.; Issitt, R. W.; Jannot, A. S.; Jouhet, V.; Kavuluru, R.; Keller, M. S.; Kirchoff, K.; Klann, J. G.; Krantz, I. D.; Kraska, D.; Krishnamurthy, A. K.; L'Yi, S.; Leblanc, J.; Leite, A. R. R.; Lemaitre, G.; Lenert, L.; Leprovost, D.; Liu, M.; Lozano-Zahonero, S.; Lynch, K. E.; Mahmood, S.; Maidlow, S.; Makoudjou Tchendjou, A. C.; Malovini, A.; Mandl, K. D.; Mao, C.; Maram, A.; Martel, P.; Masino, A. J.; Matheny, M. E.; Maulhardt, T.; Mazzitelli, M.; Mcduffie, M. T.; Mensch, A.; Ashraf, F.; Milano, M.; Minicucci, M. F.; Moal, B.; Moraleda, C.; Morris, J. S.; Moshal, K. L.; Mousavi, S.; Murad, D. A.; Murphy, S. N.; Naughton, T. P.; Neuraz, A.; Norman, J. B.; Obeid, J.; Okoshi, M. P.; Olson, K. L.; Orlova, N.; Ostasiewski, B. D.; Palmer, N. P.; Paris, N.; Pedrera Jimenez, M.; Pfaff, E. R.; Pillion, D.; Prokosch, H. U.; Prudente, R. A.; Quiros Gonzalez, V.; Ramoni, R. B.; Raskin, M.; Rieg, S.; Roig Dominguez, G.; Rojo, P.; Saez, C.; Salamanca, E.; Sandrin, A.; Santos, J. C. C.; Savino, M.; Schuettler, J.; Scudeller, L.; Sebire, N. J.; Balazote, P. S.; Serre, P.; Serret-Larmande, A.; Shakeri, Z.; Silvio, D.; Sliz, P.; Sonday, C.; Spiridou, A.; Tan, B. W. Q.; Tan, B. W. L.; Tanni, S. E.; Taylor, D. M.; Terriza-Torres, A. I.; Tibollo, V.; Tippmann, P.; Torti, C.; Trecarichi, E. M.; Tseng, Y. -J.; Vallejos, A. K.; Varoquaux, G.; Vella, M.; Vie, J. -J.; Vitacca, M.; Wagholikar, K. B.; Waitman, L. R.; Wassermann, D.; Weber, G. M.; William, Y.; Yehya, N.; Zambelli, A.; Zhang, H. G.; Zoeller, D.; Zucco, C.; Visweswaran, S.; Mowery, D. L.; Xia, Z.
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