Changes of NGF pathway in allergic rhinoconjunctivitis: a conjunctival allergen challenge study

The involvement of neuro-inflammation has been demonstrated in asthma, allergic rhinitis (AR), conjunctivitis and atopic dermatitis. Allergic reaction is associated with local production and release of neuromediators such as Nerve Growth Factor (NGF), substance P and Calcitonine-gene related peptide. Patients with allergic diseases showed increased serum and local NGF levels during inflammation or after allergen challenge.